Gene machines

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Peptide based Molecules as Protein-Protein Interaction Inhibitors: Tools for Chemical Genetics and Therapy

Current Chemical Biology Bentham Science Publishers 6:2 (2012) 145-163

Authors:

Siddhartha Roy, Piya Ghosh, Neeladri Sekhar Roy, Abhishek Mazumder, Koushik Roy, Asit Kumar Manna, Shampa Mallick, Israr Ahmed

A Genetic Network That Balances Two Outcomes Utilizes Asymmetric Recognition of Operator Sites

Biophysical Journal Elsevier 102:7 (2012) 1580-1589

Authors:

Abhishek Mazumder, Sumita Bandyopadhyay, Amlanjyoti Dhar, Dale EA Lewis, Sunanda Deb, Sucharita Dey, Pinak Chakrabarti, Siddhartha Roy

Colorful molecular diagnostics.

Clin Chem 58:4 (2012) 659-660

Authors:

Achillefs N Kapanidis, Robert Crawford

A protein biosensor that relies on bending of single DNA molecules.

Chemphyschem 13:4 (2012) 918-922

Authors:

Robert Crawford, Douglas J Kelly, Achillefs N Kapanidis

Abstract:

A "bendy" protein sensor: A DNA-based sensor that uses folded DNA (through DNA kinks) and protein-induced bending to detect DNA-binding proteins is presented. Single-molecule sensing of a transcriptional activator (catabolite activator protein, CAP, which bends its DNA site by 80掳) is demonstrated in solution and on surfaces, both in buffers and in cell lysates. The method should allow detection of a wide range of DNA-bending proteins.

Recognition of different DNA sequences by a DNA鈥恇inding protein alters protein dynamics differentially

FEBS Letters Wiley 586:3 (2012) 258-262

Authors:

Tanumoy Mondol, Subrata Batabyal, Abhishek Mazumder, Siddhartha Roy, Samir Kumar Pal